Fig. 1
From: Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Famotidine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in mice. A–D Male C57BL/6 mice, 8–12 weeks of age, were injected with LPS (7 mg/kg) with or without famotidine (FM, 0.4 or 4 mg/kg, in 100 µl volume), intraperitoneally (IP) 30 min before LPS injection. Mice were euthanized 2.5 h after LPS administration and serum and spleen TNF and IL-6 were measured. N = 10 mice per group. *P < 0.01, **P = 0.001, ***P < 0.001. E Male C57BL/6 mice, 8–12 weeks old, were injected with LPS (6 mg/kg, IP). Famotidine (FM, 4 mg/kg) or PBS (in 100 µl volume) were injected intraperitoneally twice a day for 3 days, survival was monitored for 2 weeks. N = 30 mice per group. *P = 0.001 vs. LPS + PBS group